反应详情

温度

50 °C

A mixture of 7-benzyloxy-4-chloro-6-methoxy-quinazoline (100 mg, 0.333 mmol), K2CO3 (345 mg, 2.49 mmol) and N-(4-hydroxy-phenyl)-benzamide (106 mg, 0.499 mmol) in DMA was heated at 50° C. for 18 hours. The reaction was cooled and partitioned between ice water and EtOAc. The aqueous was extracted twice with EtOAc and the combine organic washed with water, brine, dried and concentrated. The residue was purified by column chromatography (30-100% EtOAc:Heptane) to provide the title compound as a cream solid (120 mg).

1. temperatureThe reaction was cooled
2. custompartitioned between ice water and EtOAc
3. extractionThe aqueous was extracted twice with EtOAc
4. washthe combine organic washed with water, brine
5. customdried
6. concentrationconcentrated
7. customThe residue was purified by column chromatography (30-100% EtOAc:Heptane)