Hydrochloric Acid → HCID 11616635, compound

HRID 1686025Notes

Reaction equation

HRID 1686025 reaction equation
[CH3:1][C:2]1[NH:10][C:9]2[CH:8]=[CH:7][N:6]=[C:5]([N:11]3[CH2:20][CH2:19][C:18]4[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=4)[CH2:12]3)[C:4]=2[C:3]=1[CH3:21].[ClH:22]>C(OCC)(=O)C>[ClH:22].[CH3:1][C:2]1[NH:10][C:9]2[CH:8]=[CH:7][N:6]=[C:5]([N:11]3[CH2:20][CH2:19][C:18]4[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=4)[CH2:12]3)[C:4]=2[C:3]=1[CH3:21]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 11616091HCID 11616091, compound

Product 1

HCID 11616635HCID 11616635, compoundYield 75.2%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

2,3-dimethyl-4-(1,2,3,4-tetrahydroisoquinolin-2-yl)-1H-pyrrolo[3,2-c]pyridine (1.83 g, 6.59 mmol) prepared in Example 1 was dissolved in ethyl acetate (10 ml). The reaction mixture was saturated with hydrochloric acid gas and then filtered to give the titled compound as a white solid. (Yield: 75.2%)

Workup

  1. filtrationfiltered

Sources & evidence

ORD record
ord-a13e4cf9f0b1488a8e6eee610bd7e502
Source dataset
uspto-grants-2012_04
Patent number
US08148529B2

Reaction notes

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