Hydrazine hydrate (1:1) → Cyclohexanepropanamine, alpha-methyl- (9CI)

HRID 1686136Notes

Reaction equation

HRID 1686136 reaction equation
[CH:1]1([CH2:7][CH2:8][CH:9]([N:11]2C(=O)C3C(=CC=CC=3)C2=O)[CH3:10])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.O.NN>C(O)C>[CH:1]1([CH2:7][CH2:8][CH:9]([NH2:11])[CH3:10])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 67264543HCID 67264543, compound

Product 1

HCID 15014628Cyclohexanepropanamine, alpha-methyl- (9CI)Yield 37%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of 4.60 g 2-(3-cyclohexyl-1-methylpropyl)-1H-iso indole-1,3(2H)-dione and 7.26 g of hydrazine hydrate in 60 mL ethanol was heated to 70° C. The white precipitation was filtered off after cooling to room temperature. The mixture was washed with water and evaporated. 920 mg (37%) of a colourless oil were obtained.

Workup

  1. customThe white precipitation
  2. filtrationwas filtered off
  3. washThe mixture was washed with water
  4. customevaporated

Sources & evidence

ORD record
ord-484b186c89014495931260119e3ff4b2
Source dataset
uspto-grants-2012_04
Patent number
US08148538B2

Reaction notes

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