反应详情

温度

120 °C

The product from example 1 step (iii) (0.5 g), 3-bromobenzonitrile (0.73 g), cesium carbonate (2.61 g), copper(I) chloride (0.13 g), 2,2,6,6-tetramethyl-3,5-heptanedione (0.06 ml) and NMP (10 ml) were charged to a flask and heated at 120° C. for 16 h. The mixture was partitioned between ether and 2M NaOH, the aqueous layer was acidified then extracted with EtOAc, dried (MgSO4) and evaporated under reduced pressure. The residue was purified by RPHPLC to give the title compound (0.015 g).

1. customThe mixture was partitioned between ether and 2M NaOH
2. extractionthe aqueous layer was acidified then extracted with EtOAc
3. dry with materialdried (MgSO4)
4. customevaporated under reduced pressure
5. customThe residue was purified by RPHPLC