Hydrochloric Acid → 3-Chloro-5-methoxybenzoic acid

HRID 1686397Notes

Reaction equation

HRID 1686397 reaction equation
[CH3:1][O-:2].[Na+].[Cl:4][C:5]1[CH:6]=[C:7]([CH:11]=[C:12](Cl)[CH:13]=1)[C:8]([OH:10])=[O:9].Cl>CN1C(=O)N(C)CCC1>[Cl:4][C:5]1[CH:6]=[C:7]([CH:11]=[C:12]([O:2][CH3:1])[CH:13]=1)[C:8]([OH:10])=[O:9]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 58113,5-Dichlorobenzoic acidHCID 10942334Sodium Methoxide

Product 1

HCID 129093413-Chloro-5-methoxybenzoic acid

Reagents, catalysts & solvents 1

HCID 816462(1H)-Pyrimidinone, tetrahydro-1,3-dimethyl-Solvent

Conditions

Temperature
170 °C

Procedure

Sodium methoxide (25% wt., 7 ml) was added to a stirred solution of 3,5-dichlorobenzoic acid (2 g) in DMPU (10 ml) and heated at 170° C. for 5 days. The reaction was poured onto 1M HCl (50 ml). The resulting solid formed was filtered and washed with water, then dried in vacuo to give the subtitle compound (0.8 g).

Workup

  1. customThe resulting solid formed
  2. filtrationwas filtered
  3. washwashed with water
  4. customdried in vacuo

Sources & evidence

ORD record
ord-8be0db07d59f4c8bb83965b6e3415465
Source dataset
uspto-grants-2012_04
Patent number
US08148572B2

Reaction notes

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