Acetic Acid → HCID 67263938, compound

HRID 1687603Notes

Reaction equation

HRID 1687603 reaction equation
OO.[F:3][C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([S:10][CH:11]([CH3:13])[CH3:12])[C:5]=1[N+:14]([O-:16])=[O:15].C(O)(=[O:19])C.[OH2:21]>>[F:3][C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([S:10]([CH:11]([CH3:13])[CH3:12])(=[O:19])=[O:21])[C:5]=1[N+:14]([O-:16])=[O:15]

Participants

5

Reactant 4

HCID 176Acetic AcidHCID 784Hydrogen Peroxide2×HCID 962WaterHCID 62691367HCID 62691367, compound

Product 1

HCID 67263938HCID 67263938, compound

Conditions

Temperature
100 °C

Procedure

8 M of H2O2 in Water (4.4 mL) was added to a solution of 1-Fluoro-3-isopropylsulfanyl-2-nitro-benzene (6.76 g, 0.031 mol) in Acetic acid (10 mL, 0.2 mol), and the reaction was heated at 100° C. for 16 h HPLC. Addition 2.5 eq H2O2 added. The reaction mixture was cooled and added to ice, when the product precipitated, and was collected by filtration, washed with water and dried under vacuum.

Workup

  1. additionadded
  2. temperatureThe reaction mixture was cooled
  3. additionadded to ice, when the product
  4. customprecipitated
  5. filtrationwas collected by filtration
  6. washwashed with water
  7. customdried under vacuum

Sources & evidence

ORD record
ord-e9e65266d85946b2b281038f99960d49
Source dataset
uspto-grants-2012_04
Patent number
US08148391B2

Reaction notes

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