Hydrochloric Acid → HCID 87330360, compound

HRID 1688067Notes

Reaction equation

[O:1]=[CH:2][C:3](Cl)(Cl)Cl.S([O-])([O-])(=O)=O.[Na+].[Na+].[Cl:14][C:15]1[C:21]([Cl:22])=[CH:20][CH:19]=[CH:18][C:16]=1[NH2:17].Cl.Cl.[NH2:25][OH:26]>O>[Cl:14][C:15]1[C:21]([Cl:22])=[CH:20][CH:19]=[CH:18][C:16]=1[NH:17][C:2](=[O:1])/[CH:3]=[N:25]/[OH:26]

Participants

Conditions

Temperature: 100 °C

Procedure

To a solution containing chloral (4 g, 27 mmol) and sodium sulfate (35 g, 244 mmol) in 20 mL of water was added a solution containing 2,3-dichloroaniline (4.47 g, 27.6 mmol) and 3.5 mL of concentrated HCl in 5 mL of water. To this mixture was added 6.0 g (87 mmol) of hydroxylamine hydrochloride in 10 mL of water. The reaction mixture was refluxed in a 100° C. oil bath for 10 minutes. The reaction was cooled to room temperature and 5.7 g of N-(2,3-dichloro-phenyl)-2-[(E)-hydroxyimino]-acetamide was isolated by filtration as a yellow solid (90%): MS (m/e): 233.1 (M+1).

Workup

additionwas added a solution
temperatureThe reaction was cooled to room temperature

Sources & evidence

ORD record: ord-cbc55b1acc36495fa395ab0790e3a399
Source dataset: uspto-grants-2012_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08148391B2

Reaction notes

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