1-Methylpiperazine → HCID 178463842, compound

HRID 1689557Notes

Reaction equation

HRID 1689557 reaction equation
Cl[C:2]1[N:3]=[C:4](/[N:19]=[N:20]/[C:21]2[CH:26]=[CH:25][C:24]([N:27]([CH2:30][CH3:31])[CH2:28][CH3:29])=[CH:23][CH:22]=2)[S:5][C:6]=1[CH:7]=[C:8]1[C:16](=[O:17])[C:15]2[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=2)[C:9]1=[O:18].[CH3:32][N:33]1[CH2:38][CH2:37][NH:36][CH2:35][CH2:34]1>O1CCCC1>[CH2:28]([N:27]([CH2:30][CH3:31])[C:24]1[CH:25]=[CH:26][C:21](/[N:20]=[N:19]/[C:4]2[S:5][C:6]([CH:7]=[C:8]3[C:16](=[O:17])[C:15]4[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=4)[C:9]3=[O:18])=[C:2]([N:36]3[CH2:37][CH2:38][N:33]([CH3:32])[CH2:34][CH2:35]3)[N:3]=2)=[CH:22][CH:23]=1)[CH3:29]

Participants

4

Reactant 2

HCID 531671-MethylpiperazineHCID 178463841HCID 178463841, compound

Product 1

HCID 178463842HCID 178463842, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

1.00 g (2.20 mmol) 2-[(4-chloro-2-{(E)-[4-(diethylamino)phenyl]diazenyl}-1,3-thiazol-5-yl)methylene]-1H-indene-1,3(2H)-dione and 0.30 g (2.70 mmol) 1-methylpiperazine were dissolved in 40 ml tetrahydrofurane (THF) and heated under stirring for 5 hours when thin layer chromatography (TLC) analysis indicated complete consumption of the starting material. After cooling to room temperature the formed precipitate was filtered off, washed with THF and dried in vacuum at 40° C. to obtain a dark green powder.

Workup

  1. temperatureheated
  2. customconsumption of the starting material
  3. filtrationwas filtered off
  4. washwashed with THF
  5. customdried in vacuum at 40° C.
  6. customto obtain a dark green powder

Sources & evidence

ORD record
ord-6b4e694a42434ee2a675a6672def4dcd
Source dataset
uspto-grants-2012_04
Patent number
US08152861B2

Reaction notes

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