反应详情

温度

50 °C

In dimethylformamide (5 mL), combine ethyl 5-bromo-1H-indole-2-carboxylate (1.00 g, 13.7 mmole), potassium carbonate (1.4 g, 10 mmole), and methyl iodide (280 μL, 4.50 mmole). Heat the mixture to 50° C. for 18 hours. Cool to room temperature and partition between EtOAc and water. Extract with EtOAc (3×), wash with brine (3×), dry (MgSO4) and concentrate to provide crude material. The crude material is purified on 120 g silica gel with 0 to 50% EtOAc in heptane to give 850 mg (81%) of the title compound. ES/MS m/e (81Br) 284.0 (M+H)+.

1. temperatureCool to room temperature
2. custompartition between EtOAc and water
3. extractionExtract with EtOAc (3×)
4. washwash with brine (3×)
5. dry with materialdry (MgSO4)
6. concentrationconcentrate
7. customto provide crude material
8. customThe crude material is purified on 120 g silica gel with 0 to 50% EtOAc in heptane