反应详情

Alternate Procedure: Add a solution of N-chlorosuccinimide (8.4 g, 62.8 mmol) in DMF (33 mL) to a 42° C. solution of 2,6-dichloro-benzaldehyde oxime (217 g, 1.14 mol) in DMF (700 mL). Stir for 30 minutes and then add a solution of N-chlorosuccinimide (159 g, 1.19 mol) in DMF (617 mL) while maintaining the temperature between 40° C. and 45° C. Stir for 1 hour. Cool to room temperature and stir for 2 h. The resulting solution of the title compound is used directly Step 3.

1. temperaturewhile maintaining the temperature between 40° C. and 45° C
2. stirringStir for 1 hour
3. stirringstir for 2 h