反应详情

温度

100 °C

A mixture of 2-(8-bromo-2-quinolinyl)-4,6-di-tert-butylphenol (3.3 g, 8 mmol), 2,6-dimethylaniline (1.2 mL, 10 mmol), Pd(dba)2 (0.036 g, 0.6 mmol), L=(N-[2′-(dicyclohexylphosphino)[1,1′-biphenyl]-2-yl]-N,N-dimethylamine) (0.05 g, 0.12 mmol), NaOtBu (0.36 g, 3.6 mmol), and toluene (8 mL) is stirred for 8 h under an argon atmosphere at 100° C. The mixture is then poured into water and extracted with benzene (3×50 mL). The combined organic phase is washed with water and brine, and is then concentrated. The residue is purified by column chromatography (silica gel 40, hexane/toluene 2:1). Yield: 2.17 g (60%).

1. extractionextracted with benzene (3×50 mL)
2. washThe combined organic phase is washed with water and brine
3. concentrationis then concentrated
4. customThe residue is purified by column chromatography (silica gel 40, hexane/toluene 2:1)