反应详情

To a solution of methyl-3-amino-2-thiophenecarboxylate, 20, (8.0 g) in acetonitrile (100 mL) was added potassium carbonate (7.73 g) followed by m-anisoyl chloride, 23, (7.51 mL). The reaction mixture was heated to reflux, then cooled and diluted with water. 3-(3-Methoxy-benzoylamino)-thiophene-2-carboxylic acid methyl ester, 24, (12.78 g) was subsequently collected as a white solid.

1. temperatureThe reaction mixture was heated
2. temperatureto reflux
3. temperaturecooled
4. custom3-(3-Methoxy-benzoylamino)-thiophene-2-carboxylic acid methyl ester, 24, (12.78 g) was subsequently collected as a white solid