Hydrochloric Acid → HCID 24855045, compound

HRID 1689935Notes

Reaction equation

HRID 1689935 reaction equation
F[C:2]1[CH:7]=[C:6]([C:8]2[C:9]3[S:23][CH:22]=[CH:21][C:10]=3[N:11]=[C:12]([C:14]3[CH:15]=[C:16]([OH:20])[CH:17]=[CH:18][CH:19]=3)[N:13]=2)[CH:5]=[CH:4][N:3]=1.Cl.[O:25]1CCOCC1>>[OH:20][C:16]1[CH:15]=[C:14]([C:12]2[N:13]=[C:8]([C:6]3[CH:5]=[CH:4][NH:3][C:2](=[O:25])[CH:7]=3)[C:9]3[S:23][CH:22]=[CH:21][C:10]=3[N:11]=2)[CH:19]=[CH:18][CH:17]=1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 24855050HCID 24855050, compound

Product 1

HCID 24855045HCID 24855045, compound

Procedure

A mixture of 3-[4-(2-fluoro-pyridin-4-yl)-thieno[3,2-d]pyrimidin-2-yl]-phenol, (60 mg), aqueous HCl (2M, 2 mL) and 1,4-dioxane (2 mL) was heated to reflux for 24 hours. Upon cooling, a precipitate formed; this was collected by filtration and washed with water and ether to yield the furnish the title compound (50 mg).

Workup

  1. temperaturewas heated
  2. temperatureto reflux for 24 hours
  3. temperatureUpon cooling
  4. customa precipitate formed
  5. filtrationthis was collected by filtration
  6. washwashed with water and ether
  7. customto yield the

Sources & evidence

ORD record
ord-9f51c2ce57dd4328990ebf719ef3e2e9
Source dataset
uspto-grants-2012_04
Patent number
US08153639B2

Reaction notes

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