HRID1690565

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID8471

Triethylamine

C6H15N

HCID66905444

未命名化合物

HCID86640267

未命名化合物

PRODUCTS

生成物

结构：CC(C)(C)OC(=O)CCc1ccc(NC(=O)N(c2c3ccccc3nn2-c2ccc(Cl)cc2)C2CCCCC2)c(F)c1

HCID66905341

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID11

1,2-Dichloroethane

C2H4Cl2

PROCEDURE

实验过程

In analogy to the procedure described in example 1.2, [2-(4-chloro-phenyl)-2H-indazol-3-yl]-cyclohexyl-amine (example 9.1) was reacted with 3-(3-fluoro-4-isocyanato-phenyl)-propionic acid tert-butyl ester in 1,2-dichloroethane in the presence of Et3N for 3 days under reflux conditions to give the title compound as brown oil. MS: m/e=591.3 [M+H+].

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-d6f53fdc11284b33bd6a83c37d638f0a
来源数据集: uspto-grants-2012_04
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08153663B2
来源说明: uspto-grants-2012_04

反应 SMILES

[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[C:16]([NH:17][CH:18]3[CH2:23][CH2:22][CH2:21][CH2:20][CH2:19]3)=[C:15]3[C:10]([CH:11]=[CH:12][CH:13]=[CH:14]3)=[N:9]2)=[CH:4][CH:3]=1.[C:24]([O:28][C:29](=[O:42])[CH2:30][CH2:31][C:32]1[CH:37]=[CH:36][C:35]([N:38]=[C:39]=[O:40])=[C:34]([F:41])[CH:33]=1)([CH3:27])([CH3:26])[CH3:25].CCN(CC)CC>ClCCCl>[C:24]([O:28][C:29](=[O:42])[CH2:30][CH2:31][C:32]1[CH:37]=[CH:36][C:35]([NH:38][C:39]([N:17]([C:16]2[N:8]([C:5]3[CH:6]=[CH:7][C:2]([Cl:1])=[CH:3][CH:4]=3)[N:9]=[C:10]3[C:15]=2[CH:14]=[CH:13][CH:12]=[CH:11]3)[CH:18]2[CH2:23][CH2:22][CH2:21][CH2:20][CH2:19]2)=[O:40])=[C:34]([F:41])[CH:33]=1)([CH3:27])([CH3:25])[CH3:26]