Cyclohexylamine → HCID 66905291, compound

HRID 1690591Notes

Reaction equation

HRID 1690591 reaction equation
Cl[C:2]1[N:3]([C:12]2[CH:17]=[CH:16][C:15]([Cl:18])=[CH:14][CH:13]=2)[N:4]=[C:5]2[C:10]=1[CH:9]=[CH:8][C:7]([F:11])=[CH:6]2.[CH:19]1([NH2:25])[CH2:24][CH2:23][CH2:22][CH2:21][CH2:20]1>CN1CCCC1=O>[Cl:18][C:15]1[CH:16]=[CH:17][C:12]([N:3]2[C:2]([NH:25][CH:19]3[CH2:24][CH2:23][CH2:22][CH2:21][CH2:20]3)=[C:10]3[C:5]([CH:6]=[C:7]([F:11])[CH:8]=[CH:9]3)=[N:4]2)=[CH:13][CH:14]=1

Participants

4

Reactant 2

HCID 7965CyclohexylamineHCID 66905406HCID 66905406, compound

Product 1

HCID 66905291HCID 66905291, compound

Reagents, catalysts & solvents 1

HCID 13387N-methyl-2-pyrrolidoneSolvent

Procedure

In analogy to the procedure described in example 4.1, 3-chloro-2-(4-chloro-phenyl)-6-fluoro-2H-indazole was reacted with cyclohexylamine ([108-91-8]) in N-methyl 2-pyrrolidone for 72 h at 150° C. in a sealed tube to give the title compound as yellow solid. MS: m/e=344.5 [M+H+].

Sources & evidence

ORD record
ord-7f8d712f298942029a39bc050cfe3e5f
Source dataset
uspto-grants-2012_04
Patent number
US08153663B2

Reaction notes

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