Triethylamine → HCID 178455367, compound

HRID 1690593Notes

Reaction equation

HRID 1690593 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([NH:8][C:9]2[N:10]([C:18]3[CH:23]=[CH:22][C:21]([Cl:24])=[CH:20][CH:19]=3)[N:11]=[C:12]3[C:17]=2[CH:16]=[CH:15][CH:14]=[CH:13]3)[CH:5]=[CH:6][CH:7]=1.[C:25]([Si:29]([O:32][C@H:33]1[CH2:38][CH2:37][C@H:36]([N:39]=[C:40]=[O:41])[CH2:35][CH2:34]1)([CH3:31])[CH3:30])([CH3:28])([CH3:27])[CH3:26].CCN(CC)CC>ClCCCl>[C:25]([Si:29]([CH3:31])([CH3:30])[O:32][C@H:33]1[CH2:38][CH2:37][C@H:36]([NH:39][C:40](=[O:41])[N:8]([C:4]2[CH:5]=[CH:6][CH:7]=[C:2]([Cl:1])[CH:3]=2)[C:9]2[N:10]([C:18]3[CH:19]=[CH:20][C:21]([Cl:24])=[CH:22][CH:23]=3)[N:11]=[C:12]3[C:17]=2[CH:16]=[CH:15][CH:14]=[CH:13]3)[CH2:35][CH2:34]1)([CH3:28])([CH3:27])[CH3:26]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 66905411(3-Chloro-phenyl)-[2-(4-chloro-phenyl)-2H-indazol-3-yl]-amineHCID 178455365HCID 178455365, compound

Product 1

HCID 178455367HCID 178455367, compound

Reagents, catalysts & solvents 1

HCID 111,2-DichloroethaneSolvent

Procedure

In analogy to the procedure described in example 1.2, (3-chloro-phenyl)-[2-(4-chloro-phenyl)-2H-indazol-3-yl]-amine (example 19.1) was reacted with trans-tert-butyl-(4-isocyanato-cyclohexyloxy)-dimethyl-silane (Dermatakis, Apostolos; Kabat, Marek Michal; Luk, Kin-Chun; Rossman, Pamela Loreen; So, Sung-Sau. PCT Int. Appl. (2004), WO 2004041822 A1) in 1,2-dichloroethane in the presence of Et3N (3 eq.) for 6 days under reflux conditions to give the title compound as brown solid. MS: m/e=611.2 [M+H+].

Sources & evidence

ORD record
ord-17fccb77ba21420a9f767ea8ae58d858
Source dataset
uspto-grants-2012_04
Patent number
US08153663B2

Reaction notes

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