HRID1690593

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID8471

Triethylamine

C6H15N

结构：Clc1ccc(-n2nc3ccccc3c2Nc2cccc(Cl)c2)cc1

HCID66905411

未命名化合物

结构：CC(C)(C)[Si](C)(C)O[C@H]1CC[C@H](N=C=O)CC1

HCID178455365

未命名化合物

PRODUCTS

生成物

结构：CC(C)(C)[Si](C)(C)O[C@H]1CC[C@H](NC(=O)N(c2cccc(Cl)c2)c2c3ccccc3nn2-c2ccc(Cl)cc2)CC1

HCID178455367

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID11

1,2-Dichloroethane

C2H4Cl2

PROCEDURE

实验过程

In analogy to the procedure described in example 1.2, (3-chloro-phenyl)-[2-(4-chloro-phenyl)-2H-indazol-3-yl]-amine (example 19.1) was reacted with trans-tert-butyl-(4-isocyanato-cyclohexyloxy)-dimethyl-silane (Dermatakis, Apostolos; Kabat, Marek Michal; Luk, Kin-Chun; Rossman, Pamela Loreen; So, Sung-Sau. PCT Int. Appl. (2004), WO 2004041822 A1) in 1,2-dichloroethane in the presence of Et3N (3 eq.) for 6 days under reflux conditions to give the title compound as brown solid. MS: m/e=611.2 [M+H+].

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-17fccb77ba21420a9f767ea8ae58d858
来源数据集: uspto-grants-2012_04
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08153663B2
来源说明: uspto-grants-2012_04

反应 SMILES

[Cl:1][C:2]1[CH:3]=[C:4]([NH:8][C:9]2[N:10]([C:18]3[CH:23]=[CH:22][C:21]([Cl:24])=[CH:20][CH:19]=3)[N:11]=[C:12]3[C:17]=2[CH:16]=[CH:15][CH:14]=[CH:13]3)[CH:5]=[CH:6][CH:7]=1.[C:25]([Si:29]([O:32][C@H:33]1[CH2:38][CH2:37][C@H:36]([N:39]=[C:40]=[O:41])[CH2:35][CH2:34]1)([CH3:31])[CH3:30])([CH3:28])([CH3:27])[CH3:26].CCN(CC)CC>ClCCCl>[C:25]([Si:29]([CH3:31])([CH3:30])[O:32][C@H:33]1[CH2:38][CH2:37][C@H:36]([NH:39][C:40](=[O:41])[N:8]([C:4]2[CH:5]=[CH:6][CH:7]=[C:2]([Cl:1])[CH:3]=2)[C:9]2[N:10]([C:18]3[CH:19]=[CH:20][C:21]([Cl:24])=[CH:22][CH:23]=3)[N:11]=[C:12]3[C:17]=2[CH:16]=[CH:15][CH:14]=[CH:13]3)[CH2:35][CH2:34]1)([CH3:28])([CH3:27])[CH3:26]