反应详情

温度

120 °C

A sample of 6-cyanotetralone (102 mg, 0.60 mmol) is dissolved in DMF (1 mL) and treated with sodium azide (96.8 mg, 1.5 mmol), ammonium chloride (31.9 mg, 0.60 mmol) and lithium chloride (25.3 mg, 0.60 mmol) and heated to 120° C. overnight. The reaction is diluted with ethyl acetate and extracted with water twice. The residue is purified by UV triggered reverse phase HPLC to afford the title compound as a white solid.

1. extractionextracted with water twice
2. customThe residue is purified by UV triggered reverse phase HPLC