Ethyl Acetate → HCID 24991587, compound

HRID 1690843Notes

Reaction equation

HRID 1690843 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH:8]([CH2:11][OH:12])[C:9]#[N:10].[C:13](OCC)(=[O:15])[CH3:14]>CCCCCC>[C:13]([O:12][CH2:11][CH:8]([C:3]1[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=1[Cl:1])[C:9]#[N:10])(=[O:15])[CH3:14]

Participants

4

Reactant 2

HCID 8857Ethyl AcetateHCID 66906071HCID 66906071, compound2×

Product 1

HCID 24991587HCID 24991587, compound

Reagents, catalysts & solvents 1

HCID 8058HexaneSolvent

Procedure

This ester was prepared using the procedure described in Example 5, except 2-(2-chlorophenyl)-3-hydroxypropanenitrile was used in place of 2-2-chloro-5-(difluoromethoxy)phenyl-3-hydroxypropanenitrile. The preparation of 2-(2-chlorophenyl)-3-hydroxypropanenitrile is described in Example 13. The recovered ester product was a colorless oil (70% yield), Rf 0.3 (silica gel, ethyl acetate:hexane=1:4).

Sources & evidence

ORD record
ord-863dff0948dc4e599b75a71927d31595
Source dataset
uspto-grants-2012_04
Patent number
US08153688B2

Reaction notes

Loading…