反应详情

To a mixture of 2-methyl-5-(4-((E)-2-nitro-vinyl)-benzyl)-furan (120 mg) described in Manufacturing Example 46-1-4, acetic acid (0.2 mL) and dimethyl sulfoxide (3.4 mL) was added sodium borohydride (29 mg, 0.77 mmol) at room temperature while cooling appropriately, which was stirred for 20 minutes at room temperature. Water was added to the reaction mixture, which was then extracted with ethyl acetate. The organic layer was washed with saturated aqueous sodium chloride, and was concentrated under a reduced pressure. The residue was purified by neutral silica gel column chromatography (ethyl acetate:heptane=1:5) to obtain the title compound (90 mg, 77%).

1. temperaturewhile cooling appropriately
2. extractionwas then extracted with ethyl acetate
3. washThe organic layer was washed with saturated aqueous sodium chloride
4. concentrationwas concentrated under a reduced pressure
5. customThe residue was purified by neutral silica gel column chromatography (ethyl acetate:heptane=1:5)