反应详情

To a solution of methyl 4′-[(1,1-dioxidotetrahydro-2H-thiopyran-4-yl)oxy]-2′,6′-dimethylbiphenyl-3-carboxylate (0.128 g, 0.33 mmol) in tetrahydrofuran (2 mL) was added lithium aluminum hydride (80%, 15.7 mg, 0.33 mmol) in small portions under ice-cooling, and the mixture was stirred at the same temperature for 1.5 hr. Sodium sulfate 10 hydrate (0.106 g, 0.33 mmol) was added to the reaction mixture in small portions, and the mixture was stirred at room temperature for 1 hr. The insoluble material was filtered off through celite, and the filtrate was concentrated under reduced pressure to give the title compound (0.111 g, yield 93%) as a colorless amorphous powder.

1. temperaturecooling
2. stirringthe mixture was stirred at room temperature for 1 hr
3. filtrationThe insoluble material was filtered off through celite
4. concentrationthe filtrate was concentrated under reduced pressure