Trifluoroacetic acid → HCID 66905271, compound

HRID 1692081Notes

Reaction equation

HRID 1692081 reaction equation
C([O:5][C:6]([C:8]1[CH:13]=[CH:12][C:11]([C:14]2[CH:19]=[C:18]([Cl:20])[C:17]([CH2:21][C@@H:22]3[CH2:26][CH2:25][N:24]([N:27]4[CH2:32][CH2:31][O:30][CH2:29][CH2:28]4)[C:23]3=[O:33])=[C:16]([Cl:34])[CH:15]=2)=[CH:10][CH:9]=1)=[O:7])(C)(C)C.[C:35]([OH:41])([C:37]([F:40])([F:39])[F:38])=[O:36]>ClCCl>[F:38][C:37]([F:40])([F:39])[C:35]([OH:41])=[O:36].[Cl:34][C:16]1[CH:15]=[C:14]([C:11]2[CH:12]=[CH:13][C:8]([C:6]([OH:7])=[O:5])=[CH:9][CH:10]=2)[CH:19]=[C:18]([Cl:20])[C:17]=1[CH2:21][C@@H:22]1[CH2:26][CH2:25][N:24]([N:27]2[CH2:32][CH2:31][O:30][CH2:29][CH2:28]2)[C:23]1=[O:33]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 66905104HCID 66905104, compound

Product 1

HCID 66905271HCID 66905271, compoundYield 98%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Treat a solution of (R)-3′,5′-dichloro-4′-(1-morpholin-4-yl-2-oxo-pyrrolidin-3-ylmethyl)-biphenyl-4-carboxylic acid tert-butyl ester (0.15 g) in dichloromethane (5 mL) with TFA (1 mL) and stir the reaction at room temperature for 12 hours. Remove the solvent and excess TFA in vacuo to afford 0.165 g (98%) of the title compound. MS (m/z): 449 (M+).

Workup

  1. customthe reaction at room temperature for 12 hours
  2. customRemove the solvent and excess TFA in vacuo

Sources & evidence

ORD record
ord-1b09599193244c9a8470d71d818163ec
Source dataset
uspto-grants-2012_04
Patent number
US08153807B2

Reaction notes

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