Hydrochloric Acid → HCID 11424340, compound

HRID 1692179Notes

Reaction equation

HRID 1692179 reaction equation
[CH2:1]([O:3][C:4](=[CH:10][C:11]1[CH:16]=[CH:15][C:14]([N+:17]([O-])=O)=[CH:13][CH:12]=1)[C:5]([O:7]CC)=[O:6])[CH3:2].CN(C=O)C.[OH-].[Na+].Cl>O>[CH2:1]([O:3][CH:4]([CH2:10][C:11]1[CH:12]=[CH:13][C:14]([NH2:17])=[CH:15][CH:16]=1)[C:5]([OH:7])=[O:6])[CH3:2]

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 6228DimethylformamideHCID 14798Sodium HydroxideHCID 66905768Ethyl 2-ethoxy-3-(4-nitrophenyl)prop-2-enoate

Product 1

HCID 11424340HCID 11424340, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

Ethyl 2-ethoxy-3-(4-nitrophenyl)acrylate containing 3.6 wt % DMF (26.07 g corrected, 98.3 mmol) was dissolved in IMS (500 ml) and a solution of NaOH (1.44 g, 36.1 mmol) in water (260 ml) was added. The resulting mixture was stirred at ambient temperature for 18 hr then acidified with 1M HCl (120 ml) and the resulting solid collected by filtration, washed with water (2×100 ml) and suction dried on the filter for 30 mins, followed by

Workup

  1. filtrationthe resulting solid collected by filtration
  2. washwashed with water (2×100 ml) and suction
  3. customdried on the
  4. filtrationfilter for 30 mins

Sources & evidence

ORD record
ord-20dd3ade06e74753bfce4a486f9c9ca1
Source dataset
uspto-grants-2012_04
Patent number
US08153841B2

Reaction notes

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