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HRID1692425

反应详情

EQUATION

反应方程式

HRID 1692425 的结构方程式

REACTANTS

反应物

4
反应SMILES：CCN(CC)CC
HCID8471

Triethylamine

C6H15N

反应SMILES：CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F
HCID9886157

Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1)

C10H15F6N6OP

反应SMILES：Cc1nc(-c2cccc(OC(F)(F)F)c2)nc(C2CC2)c1C(=O)N1CCC(N2CCCC2)CC1
HCID57580529

未命名化合物

反应SMILES：CC(=O)N[C@@H]1C[C@@H](CO)N(C2CCNCC2)C1.Cl.Cl
HCID66901559

未命名化合物

2 次

PRODUCTS

产物

1
反应SMILES：CC(=O)N[C@@H]1C[C@@H](CO)N(C2CCN(C(=O)c3c(C)nc(-c4cccc(OC(F)(F)F)c4)nc3C3CC3)CC2)C1
HCID57580519

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
反应SMILES：CN(C)C=O
溶剂HCID6228

Dimethylformamide

C3H7NO

PROCEDURE

实验过程

In analogy to the procedure described for intermediate 2,4-cyclopropyl-6-methyl-2-(3-trifluoromethoxy-phenyl)-pyrimidine-5-carboxylic acid (example 36) was reacted with HATU, triethylamine and N-((3R,5S)-5-hydroxymethyl-1-piperidin-4-yl-pyrrolidin-3-yl)-acetamide dihydrochloride (intermediate 8) in DMF. Subsequent purification by preparative HPLC afforded the title compound as a gum. MS: 562.3 (MH+).

WORKUP

后处理

  1. customSubsequent purification by preparative HPLC