反应详情

To a suspension of sodium hydride (60% dispersion in mineral oil, 4.67 g, 0.117 mol) in 1,4-dioxane (69 mL) was added diethyl malonate (17.7 mL, 0.117 mol) dropwise. The mixture was stirred for 1.5 hours at ambient temperature after complete addition. To this mixture was added [2-bromo-1-(chloromethyl)ethoxy]methylbenzene (prepared according to the procedure found in Organic Letters (2004), 6(11), pp. 1853-1856; 32.0 g, 0.121 mol) dropwise and the resulting mixture was stirred for 1 hour at ambient temperature, then heated at reflux for 16 hours. The mixture was cooled briefly in an ice bath and sodium hydride (60% dispersion in mineral oil, 4.67 g, 0.117 mol) was added portionwise. The mixture was heated to reflux for a further 24 hours. Upon cooling to room temperature, the mixture was poured into pH 7 buffer and brine, and the product was extracted with three portions of ethyl acetate. The combined extracts were washed with brine, dried over sodium sulfate, decanted and concentrated. Flash column chromatography, eluting with a gradient of 5-60% ethyl acetate in hexanes afforded product (26.9 g, 75%).

1. additionafter complete addition
2. customprepared
3. stirring32.0 g, 0.121 mol) dropwise and the resulting mixture was stirred for 1 hour at ambient temperature
4. temperatureheated
5. temperatureat reflux for 16 hours
6. temperatureThe mixture was cooled briefly in an ice bath
7. temperatureThe mixture was heated
8. temperatureto reflux for a further 24 hours
9. temperatureUpon cooling to room temperature
10. additionthe mixture was poured into pH 7 buffer
11. extractionbrine, and the product was extracted with three portions of ethyl acetate
12. washThe combined extracts were washed with brine
13. dry with materialdried over sodium sulfate
14. customdecanted
15. concentrationconcentrated
16. washFlash column chromatography, eluting with a gradient of 5-60% ethyl acetate in hexanes afforded product (26.9 g, 75%)