反应详情

To a solution of 5-fluoro-3-isobutyl-benzo[b]thiophene 0.55 g) in chloroform (10 ml) was added chlorosulfonic acid (1.54 g), and the resulting mixture was stirred at rt for 3 h, quenched with ice/water, and extracted with methylene chloride. The organic phases were washed with water and aqueous sodium bicarbonate solution, dried and concentrated. The residue was chromatographed on silica gel using heptane/ethyl acetate as eluent to obtain the title compound (0.49 g) as a colorless oil. MS (EI): 306.8 (M)

1. customquenched with ice/water
2. extractionextracted with methylene chloride
3. washThe organic phases were washed with water and aqueous sodium bicarbonate solution
4. customdried
5. concentrationconcentrated
6. customThe residue was chromatographed on silica gel