反应详情

Cesium carbonate (2.96 g) and 2,2,2-trifluoroethyl trifluoromethanesulfonate (1.57 g) were added to a solution of methyl 5-hydroxypyrazine-2-carboxylate (700 mg) in DMF (20 mL), and the mixture was stirred at room temperature for 20 hours. Aqueous ammonium chloride and ethyl acetate were added to the reaction solution, and the organic layer was separated. The organic layer was washed with saturated aqueous sodium chloride and dried over anhydrous magnesium sulfate. The organic layer was concentrated under reduced pressure. The residue was purified by silica gel chromatography to obtain the title compound (197 mg).

1. customthe organic layer was separated
2. washThe organic layer was washed with saturated aqueous sodium chloride
3. dry with materialdried over anhydrous magnesium sulfate
4. concentrationThe organic layer was concentrated under reduced pressure
5. customThe residue was purified by silica gel chromatography