HCID 57827413, compound → HCID 57827617, compound

HRID 1693247Notes

Reaction equation

HRID 1693247 reaction equation
[C:1]([NH:9][C:10]([NH:12][C@@:13]1([C:21]2[S:22][CH:23]=[C:24]([Br:26])[CH:25]=2)[CH2:18][CH2:17][O:16][CH2:15][C@H:14]1[CH2:19]O)=[S:11])(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>CO.Cl>[Br:26][C:24]1[CH:25]=[C:21]([C@@:13]23[N:12]=[C:10]([NH:9][C:1](=[O:8])[C:2]4[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=4)[S:11][CH2:19][C@@H:14]2[CH2:15][O:16][CH2:17][CH2:18]3)[S:22][CH:23]=1

Participants

4

Reactant 1

HCID 57827413HCID 57827413, compound

Product 1

HCID 57827617HCID 57827617, compound

Reagents, catalysts & solvents 2

HCID 313Hydrochloric AcidCatalystHCID 887MethanolSolvent

Procedure

(±)-1-Benzoyl-3-[(3R*,4S*)-4-(4-bromo-thiophen-2-yl)-3-hydroxymethyl-tetrahydro-pyran-4-yl]thiourea (233 mg) was dissolved in methanol (5 mL). Several drops of concentrated hydrochloric acid were added, followed by stirring for two hours. The reaction solution was returned to room temperature and the solvent was evaporated under reduced pressure to obtain the title compound.

Workup

  1. customwas returned to room temperature
  2. customthe solvent was evaporated under reduced pressure

Sources & evidence

ORD record
ord-91e75c91e97f4989bd5d108e8d0ed1bf
Source dataset
uspto-grants-2012_04
Patent number
US08158620B2

Reaction notes

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