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HRID1694471

反应详情

EQUATION

反应方程式

HRID 1694471 的结构方程式

REACTANTS

反应物

2
结构：[Li+].[OH-]
HCID3939

Lithium hydroxide anhydrous

HLiO

结构：COC(=O)c1sc(C2CCC(=O)CC2)cc1N(C(=O)[C@H]1CC[C@H](C)CC1)[C@H]1CC[C@H](OC)CC1
HCID178499305

未命名化合物

PRODUCTS

生成物

1
结构：CO[C@H]1CC[C@H](N(c2cc(C3CCC(=O)CC3)sc2C(=O)O)C(=O)[C@H]2CC[C@H](C)CC2)CC1
HCID178496601

未命名化合物

PROCEDURE

实验过程

The product from step IV (61 mg) was hydrolyzed with lithium hydroxide as described earlier (example 3, step VIII) to afford after column purification on silica gel (CH2Cl2-MeOH) 23 mg (39%) of 3-[(trans-4-methoxy-cyclohexyl)-(trans-4-methyl-cyclohexanecarbonyl)-amino]-5-(4-oxocyclohexyl)-thiophene-2-carboxylic acid.

WORKUP

后处理

  1. customto afford
  2. customafter column purification on silica gel (CH2Cl2-MeOH) 23 mg (39%) of 3-[(trans-4-methoxy-cyclohexyl)-(trans-4-methyl-cyclohexanecarbonyl)-amino]-5-(4-oxocyclohexyl)-thiophene-2-carboxylic acid