反应详情

A mixture of triphenylphospine (0.92 g, 3.5 mmol) and CCl4 (4 mL) was stirred for 10 min. and then a solution of 1-(5-fluoropyridin-2-yl)ethanol (0.25 g, 1.7 mmol) in DCM (2 mL) was added. After 18 h, pentane (20 mL) was added, the solid material was removed by filtration and the filtrate was concentrated in vacuo. The residue was purified by flash column chromatography (eluent heptane:ethyl acetate 3:1) affording the title compound (8 mg, 3% yield).

1. waitAfter 18 h
2. customthe solid material was removed by filtration
3. concentrationthe filtrate was concentrated in vacuo
4. customThe residue was purified by flash column chromatography (eluent heptane:ethyl acetate 3:1)