反应详情

温度

80 °C

A mixture of 7-hydroxy-3-(4-methoxyphenyl)chromen-4-one (0.86 g, 3.21 mmol), epichlorohydrin (1.25 ml, 16 mmol) and potassium carbonate (0.89 g, 6.42 mmol) in dimethylformamide (20 ml) was stirred at 80° C. for 3 hours. After removing solvent under reduced pressure, water was added to the residue, and the precipitate filtered off and washed with water. The crude product was purified by chromatography on silica gel, eluting with ethyl acetate/hexanes. (1:4 to 2:3), to afford 3-(4-methoxyphenyl)-7-(oxiran-2-ylmethoxy)chromen-4-one.

1. customAfter removing solvent under reduced pressure, water
2. additionwas added to the residue
3. filtrationthe precipitate filtered off
4. washwashed with water
5. customThe crude product was purified by chromatography on silica gel
6. washeluting with ethyl acetate/hexanes