反应详情

tert-Butyl bromoacetate (2.6 ml) was added to a stirred mixture of 4-bromo-2-chlorophenol (3 g) and potassium carbonate (6.2 g) in DMF (40 ml) at RT. After 16 h the reaction was partitioned between diethylether and water, the organics separated, dried and evaporated under reduced pressure. The residue was purified by chromatography on silica eluting with 4% EtOAc/iso-hexane. Yield 4.05 g

1. customAfter 16 h the reaction was partitioned between diethylether and water
2. customthe organics separated, dried
3. customevaporated under reduced pressure
4. customThe residue was purified by chromatography on silica eluting with 4% EtOAc/iso-hexane