Pinacol → HCID 67279732, compound

HRID 1694737Notes

Reaction equation

HRID 1694737 reaction equation
[OH:1][C:2]([C:5]([OH:8])([CH3:7])[CH3:6])([CH3:4])[CH3:3].[C:9]1([CH2:15][O:16][C:17]2[CH:22]=[CH:21][C:20]([C:23]([F:26])([F:25])[F:24])=[CH:19][C:18]=2[B:27](O)O)[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1>CCOCC>[CH3:3][C:2]1([CH3:4])[C:5]([CH3:7])([CH3:6])[O:8][B:27]([C:18]2[CH:19]=[C:20]([C:23]([F:26])([F:25])[F:24])[CH:21]=[CH:22][C:17]=2[O:16][CH2:15][C:9]2[CH:10]=[CH:11][CH:12]=[CH:13][CH:14]=2)[O:1]1

Participants

4

Reactant 2

HCID 6425PinacolHCID 230053392-Benzyloxy-5-trifluoromethylphenylboronic acid

Product 1

HCID 67279732HCID 67279732, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent2×

Procedure

Pinacol (1.82 g) was added to a solution of the product from example 32 step (ii) (4.54 g) in ether (40 ml) and stirred at RT for 20 h. The reaction was diluted with ether (100 ml), washed with brine, dried (MgSO4) and evaporated. Yield 5.7 g.

Workup

  1. washwashed with brine
  2. dry with materialdried (MgSO4)
  3. customevaporated

Sources & evidence

ORD record
ord-60768b1a4fa14a2bb7f9daacf7884501
Source dataset
uspto-grants-2012_04
Patent number
US08158820B2

Reaction notes

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