HCID 86654990, compound → HCID 86654989, compound

HRID 1694757Notes

Reaction equation

HRID 1694757 reaction equation
[CH2:1]([S:3]([C:6]1[CH:11]=[CH:10][C:9]([C:12]2[C:17]([CH3:18])=[C:16]([N+:19]([O-])=O)[CH:15]=[CH:14][C:13]=2[O:22][CH2:23][C:24]([O:26][CH3:27])=[O:25])=[CH:8][CH:7]=1)(=[O:5])=[O:4])[CH3:2]>CCOC(C)=O.[Pd]>[NH2:19][C:16]1[CH:15]=[CH:14][C:13]([O:22][CH2:23][C:24]([O:26][CH3:27])=[O:25])=[C:12]([C:9]2[CH:10]=[CH:11][C:6]([S:3]([CH2:1][CH3:2])(=[O:4])=[O:5])=[CH:7][CH:8]=2)[C:17]=1[CH3:18]

Participants

4

Reactant 1

HCID 86654990HCID 86654990, compound

Product 1

HCID 86654989HCID 86654989, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 8857Ethyl AcetateSolvent

Procedure

10% Pd/C (0.15 g) was added to a solution of the product from example 165 step (ii) in EtOAc (20 ml) was hydrogenated at RT and 3 bar for 2 h. The mixture was filtered through celite and the filtrate evaporated to give the sub-title compound. Yield 1.4 g.

Workup

  1. customwas hydrogenated at RT
  2. filtrationThe mixture was filtered through celite
  3. customthe filtrate evaporated

Sources & evidence

ORD record
ord-a8bafd334d894fc98beea8142499ba07
Source dataset
uspto-grants-2012_04
Patent number
US08158820B2

Reaction notes

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