Trifluoroacetic acid → HCID 178466248, compound

HRID 1694813Notes

Reaction equation

HRID 1694813 reaction equation
[CH2:1]([O:3][C:4]1[CH:9]=[C:8]([CH2:10][CH3:11])[C:7]([CH:12]([C:14]2[N:15]=[CH:16][N:17](C(C3C=CC=CC=3)(C3C=CC=CC=3)C3C=CC=CC=3)[CH:18]=2)O)=[C:6]([CH2:38][CH3:39])[CH:5]=1)[CH3:2].C([SiH](CC)CC)C.FC(F)(F)C(O)=O>ClCCl>[CH2:1]([O:3][C:4]1[CH:9]=[C:8]([CH2:10][CH3:11])[C:7]([CH2:12][C:14]2[N:15]=[CH:16][NH:17][CH:18]=2)=[C:6]([CH2:38][CH3:39])[CH:5]=1)[CH3:2]

Participants

5

Reactant 3

HCID 6422Trifluoroacetic acidHCID 12052TriethylsilaneHCID 58951941HCID 58951941, compound

Product 1

HCID 178466248HCID 178466248, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Prepared in analogy to Example 57(e) from rac-(4-ethoxy-2,6-diethyl-phenyl)-(1-trityl-1H-imidazol-4-yl)-methanol, triethylsilane and trifluoroacetic acid in dichloromethane in a pressure tube at 70° C. for 16 h. White crystalline solid. MS (ISP): 259.4 ([M+H]+).

Sources & evidence

ORD record
ord-5c56d72b137b4410aa967282912b8f04
Source dataset
uspto-grants-2012_04
Patent number
US08158668B2

Reaction notes

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