Trifluoroacetic acid → HCID 178436849, compound

HRID 1694825Notes

Reaction equation

HRID 1694825 reaction equation
CN(C)S([N:6]1[CH:10]=[C:9]([CH:11]([C:13]2[C:18]([CH2:19][CH3:20])=[CH:17][C:16]([O:21][C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=3)=[CH:15][C:14]=2[CH2:28][CH3:29])O)[N:8]=[C:7]1[Si](C(C)(C)C)(C)C)(=O)=O.C([SiH](CC)CC)C.FC(F)(F)C(O)=O>ClCCl>[CH2:28]([C:14]1[CH:15]=[C:16]([O:21][C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)[CH:17]=[C:18]([CH2:19][CH3:20])[C:13]=1[CH2:11][C:9]1[N:8]=[CH:7][NH:6][CH:10]=1)[CH3:29]

Participants

5

Reactant 3

HCID 6422Trifluoroacetic acidHCID 12052TriethylsilaneHCID 58951960HCID 58951960, compound

Product 1

HCID 178436849HCID 178436849, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Prepared in analogy to Example 57(e) from rac-2-(tert-butyl-dimethyl-silanyl)-4-[(2,6-diethyl-4-phenoxy-phenyl)-hydroxy-methyl]-imidazole-1-sulfonic acid dimethylamide, triethylsilane and trifluoroacetic acid in dichloromethane in a pressure tube at 100° C. for 16 h. White crystalline solid. MS (ISP): 307.3 ([M+H]+).

Sources & evidence

ORD record
ord-87bacaf44c434ef1b24697dd575ac7f4
Source dataset
uspto-grants-2012_04
Patent number
US08158668B2

Reaction notes

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