反应详情

温度

50 °C

In a flask, cyanoacetic acid (5.0 g, 58.8 mmol, 1.2 eq) was dissolved in acetic anhydride (50 mL) and heated at 50° C. Indole (5.8 g, 50.0 mmol, 1.0 eq) was added and the reaction was heated at 80° C. for 5 min. A white precipitate crushed out of the solution; the reaction was cooled to room temperature and then filtered. The solid obtained (620.0 mg, 85% yield) was used for the next step without further purification.

1. temperaturethe reaction was heated at 80° C. for 5 min
2. customA white precipitate crushed out of the solution
3. temperaturethe reaction was cooled to room temperature
4. filtrationfiltered
5. customThe solid obtained (620.0 mg, 85% yield)
6. customwas used for the next step without further purification