2-Amino-2-methyl-1-propanol → HCID 178434999, compound

HRID 1695483Notes

Reaction equation

HRID 1695483 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:12](/[CH:13]=[CH:14]/[C:15]3[CH:16]=[C:17]([C:20]([OH:22])=O)[NH:18][N:19]=3)=[C:11]([CH3:23])[O:10][N:9]=2)=[CH:4][CH:3]=1.[OH:24][CH2:25][C:26]([NH2:29])([CH3:28])[CH3:27]>>[OH:24][CH2:25][C:26]([NH:29][C:20]([C:17]1[NH:18][N:19]=[C:15](/[CH:14]=[CH:13]/[C:12]2[C:8]([C:5]3[CH:4]=[CH:3][C:2]([F:1])=[CH:7][CH:6]=3)=[N:9][O:10][C:11]=2[CH3:23])[CH:16]=1)=[O:22])([CH3:28])[CH3:27]

Participants

3

Reactant 2

HCID 118072-Amino-2-methyl-1-propanolHCID 178435004HCID 178435004, compound

Product 1

HCID 178434999HCID 178434999, compoundYield 36%

Procedure

As described for example 132, 5-{(E)-2-[3-(4-fluoro-phenyl)-5-methyl-isoxazol-4-yl]-vinyl}-2H-pyrazole-3-carboxylic acid was converted, using 2-hydroxy-1,1-dimethylethylamine instead of morpholine, to the title compound (11 mg, 36%) which was obtained as an off white solid. MS: m/e=385.2 [M+H]+.

Sources & evidence

ORD record
ord-0eb731f97dd24bfab00f93cec0f34ade
Source dataset
uspto-grants-2012_04
Patent number
US08163728B2

Reaction notes

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