Sulfuric Acid → HCID 57960319, compound

HRID 1695554Notes

Reaction equation

HRID 1695554 reaction equation
Cl.[NH2:2][C:3]1[C:4]([C:9]2([OH:15])[CH2:14][CH2:13][NH:12][CH2:11][CH2:10]2)=[N:5][CH:6]=[CH:7][CH:8]=1.S(=O)(=O)(O)O.C(=O)([O-])[O-].[K+].[K+].Br[CH2:28][C:29]([NH2:31])=[O:30]>C(#N)C>[NH2:2][C:3]1[C:4]([C:9]2[CH2:14][CH2:13][N:12]([CH2:28][C:29]([NH2:31])=[O:30])[CH2:11][CH:10]=2)=[N:5][CH:6]=[CH:7][CH:8]=1.[NH2:2][C:3]1[C:4]([C:9]2([OH:15])[CH2:10][CH2:11][N:12]([CH2:28][C:29]([NH2:31])=[O:30])[CH2:13][CH2:14]2)=[N:5][CH:6]=[CH:7][CH:8]=1

Participants

7

Reactant 4

HCID 1118Sulfuric AcidHCID 11430Potassium CarbonateHCID 696322-BromoacetamideHCID 67269726HCID 67269726, compound

Product 2

HCID 57960319HCID 57960319, compoundHCID 57960679HCID 57960679, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

4-(3-Aminopyridine-2-yl)piperidin-4-ol hydrochloride was allowed to undergo the reaction with 20% sulfuric acid. This was allowed to undergo the reaction with potassium carbonate and 2-bromoacetamide in acetonitrile to obtain 2-(3-amino-3′,6′-dihydro-2,4′-bipyridine-1′(2′H)-yl)acetamide and 2-[4-(3-aminopyridine-2-yl)-4-hydroxypiperidin-1-yl]acetamide.

Sources & evidence

ORD record
ord-711a623ee54044b796c44f6e338db2e7
Source dataset
uspto-grants-2012_04
Patent number
US08163746B2

Reaction notes

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