2-Methoxyethylamine → HCID 178495942, compound

HRID 1695612Notes

Reaction equation

HRID 1695612 reaction equation
Cl[CH2:2][C:3]([NH:5][C:6]1[CH:26]=[CH:25][C:9]2[N:10]=[C:11]([NH:14][CH:15]3[C:19]4[CH:20]=[CH:21][C:22]([F:24])=[CH:23][C:18]=4[O:17][CH2:16]3)[O:12][CH2:13][C:8]=2[CH:7]=1)=[O:4].[CH3:27][O:28][CH2:29][CH2:30][NH2:31]>>[F:24][C:22]1[CH:21]=[CH:20][C:19]2[CH:15]([NH:14][C:11]3[O:12][CH2:13][C:8]4[CH:7]=[C:6]([NH:5][C:3](=[O:4])[CH2:2][NH:31][CH2:30][CH2:29][O:28][CH3:27])[CH:26]=[CH:25][C:9]=4[N:10]=3)[CH2:16][O:17][C:18]=2[CH:23]=1

Participants

3

Reactant 2

HCID 80182-MethoxyethylamineHCID 178520798HCID 178520798, compound

Product 1

HCID 178495942HCID 178495942, compoundYield 68.9%

Procedure

Prepared from the above described rac-2-chloro-N- [2-(6-fluoro-2,3-dihydro-benzofuran-3-ylamino)-4H-benzo[d][1,3]oxazin-6-yl]-acetamide (50 mg, 0.133 mmol, HPLC 1.056 min) and 2-methoxyethylamine (230 ul, 2.66 mmol) according to the procedure described for Example 3 step B. Obtained the title compound as a white solid (38 mg, 70%, HPLC 0.466 min 100%), MS (ISP) m/e=415.3 [(M+H)+].

Workup

  1. customPrepared from the

Sources & evidence

ORD record
ord-52525d1f593c4df5a3557b17a7362292
Source dataset
uspto-grants-2012_04
Patent number
US08163740B2

Reaction notes

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