1-Methylpiperazine → HCID 178480915, compound

HRID 1695614Notes

Reaction equation

HRID 1695614 reaction equation
Cl[CH2:2][C:3]([NH:5][C:6]1[CH:26]=[CH:25][C:9]2[N:10]=[C:11]([NH:14][CH:15]3[C:19]4[CH:20]=[CH:21][C:22]([F:24])=[CH:23][C:18]=4[O:17][CH2:16]3)[O:12][CH2:13][C:8]=2[CH:7]=1)=[O:4].[CH3:27][N:28]1[CH2:33][CH2:32][NH:31][CH2:30][CH2:29]1>>[F:24][C:22]1[CH:21]=[CH:20][C:19]2[CH:15]([NH:14][C:11]3[O:12][CH2:13][C:8]4[CH:7]=[C:6]([NH:5][C:3](=[O:4])[CH2:2][N:31]5[CH2:32][CH2:33][N:28]([CH3:27])[CH2:29][CH2:30]5)[CH:26]=[CH:25][C:9]=4[N:10]=3)[CH2:16][O:17][C:18]=2[CH:23]=1

Participants

3

Reactant 2

HCID 531671-MethylpiperazineHCID 178520798HCID 178520798, compound

Product 1

HCID 178480915HCID 178480915, compoundYield 99.2%

Procedure

Prepared from rac-2-chloro-N-[2-(6-fluoro-2,3-dihydro-benzofuran-3-ylamino)-4H-benzo[d][1,3]oxazin-6-yl]-acetamide (Example 42 step A) (50 mg, 0.133 mmol, HPLC 1.056 min) and 1-methylpiperazine (300 ul, 2.66 mmol) according to the procedure described for Example 3 step B. Obtained the title compound as a white solid (58 mg, 99%, HPLC 0.468 min 100%), MS (ISP) m/e=440.3 [(M+H)+].

Sources & evidence

ORD record
ord-8f601d0cea1c4290bb2d585158a73ebb
Source dataset
uspto-grants-2012_04
Patent number
US08163740B2

Reaction notes

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