2-Amino-6-(trifluoromethyl)pyridine → HCID 178488331, compound

HRID 1695626Notes

Reaction equation

HRID 1695626 reaction equation
Br[C:2]1[CH:23]=[CH:22][C:5]2[N:6]=[C:7]([NH:10][CH:11]3[C:15]4[C:16]([O:20][CH3:21])=[CH:17][CH:18]=[CH:19][C:14]=4[O:13][CH2:12]3)[O:8][CH2:9][C:4]=2[CH:3]=1.[NH2:24][C:25]1[CH:30]=[CH:29][CH:28]=[C:27]([C:31]([F:34])([F:33])[F:32])[N:26]=1>>[CH3:21][O:20][C:16]1[C:15]2[CH:11]([NH:10][C:7]3[O:8][CH2:9][C:4]4[CH:3]=[C:2]([NH:24][C:25]5[CH:30]=[CH:29][CH:28]=[C:27]([C:31]([F:33])([F:32])[F:34])[N:26]=5)[CH:23]=[CH:22][C:5]=4[N:6]=3)[CH2:12][O:13][C:14]=2[CH:19]=[CH:18][CH:17]=1

Participants

3

Reactant 2

HCID 8210242-Amino-6-(trifluoromethyl)pyridineHCID 178488327HCID 178488327, compound

Product 1

HCID 178488331HCID 178488331, compoundYield 12.3%

Procedure

The title compound (28 mg, 12%), light brown foam, MS (ISP): m/e=457.3 (M+H+), was prepared in accordance with the general method of Example 35 from rac-(6-bromo-4H-benzo[d][1,3]oxazin-2-yl)-(4-methoxy-2,3-dihydro-benzofuran-3-yl)-amine (Example 54) (188 mg, 0.5 mmol) and commercially available 2-amino-6-trifluoromethyl-pyridine (162 mg, 1.0 mmol).

Sources & evidence

ORD record
ord-7bd052a82c80425e9cc9e5e57158e7f5
Source dataset
uspto-grants-2012_04
Patent number
US08163740B2

Reaction notes

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