Benzaldehyde → HCID 178420323, compound

HRID 1695650Notes

Reaction equation

HRID 1695650 reaction equation
[CH:1]1([NH:8][C:9]2[O:10][CH2:11][C:12]3[CH:18]=[C:17]([NH2:19])[CH:16]=[CH:15][C:13]=3[N:14]=2)[CH2:7][CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[CH:20](=O)[C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1>>[CH2:20]([NH:19][C:17]1[CH:16]=[CH:15][C:13]2[N:14]=[C:9]([NH:8][CH:1]3[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7]3)[O:10][CH2:11][C:12]=2[CH:18]=1)[C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1

Participants

3

Reactant 2

HCID 240BenzaldehydeHCID 178507250HCID 178507250, compound

Product 1

HCID 178420323HCID 178420323, compoundYield 96.2%

Procedure

Prepared from N2-cycloheptyl-4H-benzo[d][1,3]oxazine-2,6-diamine (example 92) (200 mg, 0.77 mmol) and benzaldehyde (90 mg, 0.85 mmol) according to the procedure described for example 88. Obtained the title compound as a yellow oil (259 mg, 96%), MS (ISP) m/e=350.5 [(M+H)+].

Sources & evidence

ORD record
ord-90085e01e0cb48978b88ace10552e501
Source dataset
uspto-grants-2012_04
Patent number
US08163740B2

Reaction notes

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