Diisopropylethylamine → HCID 178494600, compound

HRID 1695706Notes

Reaction equation

HRID 1695706 reaction equation
Cl[CH2:2][C:3]([NH:5][C:6]1[CH:25]=[CH:24][C:9]2[N:10]=[C:11]([NH:14][C@H:15]3[C:23]4[C:18](=[CH:19][CH:20]=[CH:21][CH:22]=4)[CH2:17][CH2:16]3)[O:12][CH2:13][C:8]=2[CH:7]=1)=[O:4].Cl.[CH3:27][O:28][CH2:29][CH:30]1[CH2:35][NH:34][CH2:33][CH:32]([CH2:36][O:37][CH3:38])[N:31]1[CH3:39].C(N(C(C)C)CC)(C)C>C(#N)C>[CH3:38][O:37][CH2:36][CH:32]1[N:31]([CH3:39])[CH:30]([CH2:29][O:28][CH3:27])[CH2:35][N:34]([CH2:2][C:3]([NH:5][C:6]2[CH:25]=[CH:24][C:9]3[N:10]=[C:11]([NH:14][C@H:15]4[C:23]5[C:18](=[CH:19][CH:20]=[CH:21][CH:22]=5)[CH2:17][CH2:16]4)[O:12][CH2:13][C:8]=3[CH:7]=2)=[O:4])[CH2:33]1

Participants

5

Reactant 3

HCID 81531DiisopropylethylamineHCID 67277667HCID 67277667, compoundHCID 178520800HCID 178520800, compound

Product 1

HCID 178494600HCID 178494600, compoundYield 11%

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

Prepared from 2-chloro-N-[2-((R)-indan-1-ylamino)-4H-benzo[d][1,3]oxazin-6-yl]-acetamide (Example 3 step A) (100 mg, 0.281 mmol), the above described (2SR,6SR)-2,6-bis-methoxymethyl-1-methyl-piperazine hydrochloride (69.5 mg, 0.309 mmol) and diisopropylethyl amine (144 ul, 0.843 mmol) in acetonitrile (2 ml) according to the procedure described for Example 3 step B. Obtained the title compound as a light yellow solid (15 mg, 11%), MS (ISP) m/e=508.4 [(M+H)+].

Sources & evidence

ORD record
ord-102c6ac7f2784c718e0725af6c604267
Source dataset
uspto-grants-2012_04
Patent number
US08163740B2

Reaction notes

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