HCID 58255828, compound → HCID 58255733, compound

HRID 1695717Notes

Reaction equation

HRID 1695717 reaction equation
[CH3:1][C:2]1[CH:3]=[C:4]([C:8]2[CH:9]=[C:10]([N+:23]([O-])=O)[C:11]3[C:15]([CH:16]=2)=[N:14][N:13]([CH:17]2[CH2:22][CH2:21][CH2:20][CH2:19][O:18]2)[CH:12]=3)[CH:5]=[CH:6][CH:7]=1>C(OCC)(=O)C.[Pd]>[CH3:1][C:2]1[CH:3]=[C:4]([C:8]2[CH:9]=[C:10]([NH2:23])[C:11]3[C:15]([CH:16]=2)=[N:14][N:13]([CH:17]2[CH2:22][CH2:21][CH2:20][CH2:19][O:18]2)[CH:12]=3)[CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 1

HCID 58255828HCID 58255828, compound

Product 1

HCID 58255733HCID 58255733, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 8857Ethyl AcetateSolvent

Procedure

6-(3-Methylphenyl)-4-nitro-2-(tetrahydro-2H-pyran-2-yl)-2H-indazole (422 mg, 1.25 mmol) was dissolved in ethyl acetate (25 ml) and reduced using the H-cube (available from ThalesNano) with a Pd/C catalyst cartridge at a pressure of up to 80 bar. The solvent was removed in vacuo to give the title compound, 286 mg.

Workup

  1. customThe solvent was removed in vacuo

Sources & evidence

ORD record
ord-4c0ffdce15534056bad9fd015d56ee03
Source dataset
uspto-grants-2012_04
Patent number
US08163743B2

Reaction notes

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