反应详情

DIPEA (82 mg, 0.635 mmol) and cyclopropanecarbonyl chloride (15 mg, 0.14 mmol) were added to 2-(tetrahydro-2H-pyran-2-yl)-6-[4-(tetrahydro-2H-pyran-2-yloxy)phenyl]-2H-indazol-4-amine (50 mg, 0.127 mmol) in DCM (1 ml) and the reaction was stirred for 1 h. The solvent was removed under a stream of nitrogen. The residue was dissolved in MeOH (2 ml), 4 M HCl in 1,4-dioxane (2 ml) was added and the reaction was stirred for 1 h. The solvent was removed in vacuo. The residue was purified by MDAP (Method B), dried under a stream of nitrogen then freeze dried to give the title compound, 17 mg.

1. customThe solvent was removed under a stream of nitrogen
2. dissolutionThe residue was dissolved in MeOH (2 ml)
3. addition4 M HCl in 1,4-dioxane (2 ml) was added
4. stirringthe reaction was stirred for 1 h
5. customThe solvent was removed in vacuo
6. customThe residue was purified by MDAP (Method B)
7. customdried under a stream of nitrogen
8. customthen freeze dried