Hexafluorophosphate → N-[4-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-a]pyridin-6-yl}oxy)phenyl]-2-oxo-1-(4-fluorophenyl)-1,2-dihydropyridine-3-carboxamide

HRID 169618Notes

Reaction equation

HRID 169618 reaction equation
[CH3:74][N:75]([CH3:76])[C:77](=[O:78])[CH3:79].[CH:65]([N:66]([CH2:67][CH3:68])[CH:69]([CH3:70])[CH3:71])([CH3:72])[CH3:73].[F:24][c:25]1[cH:26][cH:27][c:28](-[n:31]2[c:32](=[O:40])[c:33]([C:37](=[O:38])[OH:39])[cH:34][cH:35][cH:36]2)[cH:29][cH:30]1.[NH2:1][c:2]1[cH:3][cH:4][c:5]([O:6][c:7]2[cH:8][cH:9][c:10]3[n:11]([cH:12]2)[cH:13][c:14]([NH:16][C:17](=[O:18])[CH:19]2[CH2:20][CH2:21]2)[n:15]3)[cH:22][cH:23]1.[P-:41]([F:42])([F:43])([F:44])([F:45])([F:46])[F:47].[n:48]1([O:49][C:50]([N:51]([CH3:52])[CH3:53])=[N+:54]([CH3:55])[CH3:56])[c:57]2[n:58][cH:59][cH:60][cH:61][c:62]2[n:63][n:64]1>>[NH:1]([c:2]1[cH:3][cH:4][c:5]([O:6][c:7]2[cH:8][cH:9][c:10]3[n:11]([cH:12]2)[cH:13][c:14]([NH:16][C:17](=[O:18])[CH:19]2[CH2:20][CH2:21]2)[n:15]3)[cH:22][cH:23]1)[C:37]([c:33]1[c:32](=[O:40])[n:31](-[c:28]2[cH:27][cH:26][c:25]([F:24])[cH:30][cH:29]2)[cH:36][cH:35][cH:34]1)=[O:38]

Participants

7

Reactant 6

HCID 9886HexafluorophosphateHCID 31374DimethylacetamideHCID 81531DiisopropylethylamineHCID 4641409(Dimethylamino)-N,N-dimethyl(3H-(1,2,3)triazolo(4,5-b)pyridin-3-yloxy)methaniminiumHCID 210815271-(4-Fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxylic acidHCID 58158625N-[6-(4-aminophenoxy)imidazo[1,2-a]pyridin-2-yl]cyclopropanecarboxamide

Product 1

HCID 58158574N-[4-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-a]pyridin-6-yl}oxy)phenyl]-2-oxo-1-(4-fluorophenyl)-1,2-dihydropyridine-3-carboxamide

Sources & evidence

ORD record
ord-a366bf944a7b40d98ac9c5638bec4d64
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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