反应详情

温度

100 °C

The solution of 5.9 g of carbonyldiimidazole in 10 ml of N-methylpyrrolidone is added dropwise to the solution of 5 g of methyl 3,4-diaminobenzoate in 10 ml of N-methylpyrrolidone, and the mixture is heated to 100° C. for 2 hours. After cooling to 60° C., 5 ml of methanol were added dropwise and then the mixture was stirred at room temperature with 150 ml of water, and the precipitate was filtered off with suction, washed with isopropanol and dried under reduced pressure.

1. temperatureAfter cooling to 60° C.
2. filtrationthe precipitate was filtered off with suction
3. washwashed with isopropanol
4. customdried under reduced pressure