Methylamine → HCID 67274029, compound

HRID 1696774Notes

Reaction equation

HRID 1696774 reaction equation
C(O[C:4](=[O:13])[C:5]1[CH:10]=[C:9]([NH2:11])[N:8]=[C:7]([NH2:12])[CH:6]=1)C.[CH3:14][NH2:15]>CO>[NH2:11][C:9]1[CH:10]=[C:5]([CH:6]=[C:7]([NH2:12])[N:8]=1)[C:4]([NH:15][CH3:14])=[O:13]

Participants

4

Reactant 2

HCID 6329MethylamineHCID 57357157Ethyl 2,6-diaminopyridine-4-carboxylate

Product 1

HCID 67274029HCID 67274029, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
70 °C

Procedure

A mixture of 0.270 g 2,6-diaminoisonicotinic acid ethyl ester and 5 ml of a 2M solution of methylamine in methanol was stirred at 70° C. for 24 h. The solvent were evaporated and the residue was triturated with ethyl acetate to yield 0.214 g of the title compound as light brown solid. MS (ISP) M+H+=167.4

Workup

  1. customThe solvent were evaporated
  2. customthe residue was triturated with ethyl acetate

Sources & evidence

ORD record
ord-aea08b56640f48c29b81bec149bfe27c
Source dataset
uspto-grants-2012_04
Patent number
US08163778B2

Reaction notes

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