Hydrochloric Acid → HCID 66618519, compound

HRID 1696817Notes

Reaction equation

HRID 1696817 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][CH2:11][C@H:10]([C:14](=[O:23])[NH:15][C:16]2[CH:21]=[CH:20][C:19]([F:22])=[CH:18][CH:17]=2)[CH2:9]1)=O)(C)(C)C.[ClH:24]>ClCCl>[ClH:24].[F:22][C:19]1[CH:18]=[CH:17][C:16]([NH:15][C:14]([C@H:10]2[CH2:11][CH2:12][CH2:13][NH:8][CH2:9]2)=[O:23])=[CH:21][CH:20]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 42053071HCID 42053071, compound

Product 1

HCID 66618519HCID 66618519, compoundYield 92%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a cooled solution of (S)-3-(4-fluoro-phenylcarbamoyl)-piperidine-1-carboxylic acid tert-butyl ester (0.34 g, 1.05 mmol) in dichloromethane (5 mL) was added dropwise 5.2 mL of HCl 4N (dioxane solution) and the solution was stirred at R.T. for 45 min. The solvent was evaporated under reduced pressure to give the title compound as a white solid (0.252 g).

Workup

  1. customThe solvent was evaporated under reduced pressure

Sources & evidence

ORD record
ord-7d76c7afc99440ff99d35c0ee9ca928c
Source dataset
uspto-grants-2012_04
Patent number
US08163775B2

Reaction notes

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