Lithium Hydroxide → HCID 10038383, compound

HRID 1696899Notes

Reaction equation

HRID 1696899 reaction equation
[N:1]1([C:5]2[N:14]=[C:13]3[C:8]([C:9](=[O:24])[C:10]([C:19]([O:21]CC)=[O:20])=[CH:11][N:12]3CCC#N)=[CH:7][C:6]=2[F:25])[CH2:4][CH2:3][CH2:2]1.[Li+].[OH-]>C1COCC1.CO>[N:1]1([C:5]2[N:14]=[C:13]3[C:8]([C:9](=[O:24])[C:10]([C:19]([OH:21])=[O:20])=[CH:11][NH:12]3)=[CH:7][C:6]=2[F:25])[CH2:4][CH2:3][CH2:2]1

Participants

5

Reactant 2

HCID 3939Lithium HydroxideHCID 67275267HCID 67275267, compound

Product 1

HCID 10038383HCID 10038383, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 8028TetrahydrofuranSolvent

Procedure

A suspension of EXAMPLE 7D in THF (400 mL) and methanol (200 mL) at reflux was treated with 1M LiOH (200 mL), stirred for an 3 hours then cooled, concentrated to half volume, acidified with 10% citric acid, and filtered.

Workup

  1. temperaturethen cooled
  2. concentrationconcentrated to half volume
  3. filtrationfiltered

Sources & evidence

ORD record
ord-6123e148d8b446fa9922b39a0292ceac
Source dataset
uspto-grants-2012_04
Patent number
US08163769B2

Reaction notes

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